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Annette
L. Bunge
Professor Emeritus
BS State University of New York, Buffalo
PhD University of California, Berkeley
Transport in membranes; dermal absorption of chemicals
Research
Description
Absorption through human skin, intentional or not, of drugs or other chemicals
is an important problem which has applications in drug delivery and toxic
exposure. Manifestation of a therapeutic effect or toxicity following
dermal contact requires transdermal penetration of the chemical.
The ultimate objective of this research is to develop algorithms for predicting
the rate and extent of absorption following dermal contact with a chemical.
This prediction can then be used for health risk assessments or drug delivery
and design.
Research on this subject is conducted in collaboration with pharmaceutical
chemists, toxicologists, and dermatologists at several research facilities
around the world. The results of this research are the basis for dermal
absorption calculations recently recommended by the U.S. Environmental
Protection Agency.
The present emphasis is dermal absorption of chemicals from nonaqueous
solutions and from contaminated water and soils. The goals of these projects
are to identify the absorption mechanisms, to develop descriptive mathematical
models, and to design and conduct experiments that produce well-defined
and interpretable data.
Contact
Information
Annette L. Bunge
462 Alderson Hall
Chemical Engineering Dept.
Colorado School of Mines
Golden, CO 80401
Office: (303) 273-3722
FAX: (303) 273-3730
abunge@mines.edu
