2020 Virtual undergraduate Research symposium

FeS Cluster Inhibition Using Small Molecules


PROJECT NUMBER: 32

AUTHOR: Jaclyn Whalen, Chemistry | MENTOR: Christine Morrision, Chemistry

 

ABSTRACT

FeS clusters are present in proteins in every living organism, as well as many viruses. The SUF Pathway is the only mechanism that Bacillus subtilis has to create FeS clusters. This project worked to inhibit this pathway using a small molecule library. In order to test the small molecule library, an abundance of SufU and SufS proteins were needed. This was accomplished by transforming vectors coding for the B. subtilis proteins into E. coli cells, growing up these cells, and then isolating the proteins from them.

 

VISUAL PRESENTATION

 

AUTHOR BIOGRAPHY

Jackie is a junior majoring in Biochemistry. She is doing research into FeS cluster inhibition using small molecules. In the past, she has done research into pesticide development and the identification of genes in bacteria. She hopes to go to graduate school after receiving her bachelor’s degree and receive a doctorate in biochemistry and then go into pharmacology researching drug discovery.

 


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