Project Info
*Mathematical modeling to investigate dual-pathway inhibition by anticoagulant drugs
Karin Leiderman
kleiderman@mines.edu
The main goal of this project is to build, implement, and test computational models of a blood coagulation and the effects of combination anticoagulant therapy. The project will involve learning the basics of blood coagulation, working with and extending current mathematical models of blood coagulation, and using the models to investigate possible mechanisms underlying observed synergism in combination anticoagulation strategies. In particular, we will model the effects of low doses of aspirin and low doses of direct enzyme inhibitors, alone, and in combination, in a mathematical model of coagulation under flow. If time permits, the project may include exploration of other anticoagulants and their effects on coagulation.
More Information:
Grand Challenge: Not applicable
Mathematical Model:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200917
Anticoagulation:
https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.118.313141
Primary Contacts:
Karin Leiderman
Student Preparation
Qualifications
For this project, students should have taken MATH 307 and 331 and must have good working knowledge of MATLAB. Python and/or fortran are desired but not necessary. Students must have a strong interest in biology, biochemistry, and/or biomedical applications.
TIME COMMITMENT (HRS/WK)
4
SKILLS/TECHNIQUES GAINED
Students working on this project will gain experience building, implementing, and testing computational models of blood coagulation. Students will also be expected to participate in group meetings where they will gain experience discussing and presenting their work to other students and faculty.
MENTORING PLAN
I will meet with the student one-on-one, once a week, to discuss research progress. Additionally, the student will be integrated into my weekly research group meetings where they will meet other undergraduate and graduate students working in mathematical biology. I will also work closely with the student on professional development topics, including scientific presentations and writing.
PREFERRED STUDENT STATUS
Junior
Senior