Project Info
Multiscale modeling of circadian rhythms in neurons of the suprachiasmatic nucleus
Cecilia Behn | cdinizbe@mines.edu
The molecular clock within the SCN operates on a 24h timescale to modulate the electrical activity of SCN neurons on a ms timescale. Understanding the interactions between these two systems is necessary to describe how inputs that affect SCN electrophysiology are transmitted to the clock and result in specific patterns of phase shifting.
More Information
“Diekman et al., “”Causes and Consequences of Hyperexcitation in Central Clock Neurons””, PLoS Comp Bio, 2013.
Belle et al., “”Daily Electrical Silencing in the Mammalian Circadian Clock””, Science, 2009.”
Grand Engineering: Not applicable
Student Preparation
Qualifications
Familiarity with MATLAB and the basic modeling techniques covered in MATH 331 and/or MATH 472/572.
Time Commitment
20-40 hours/month
Skills/Techniques Gained
Skills in computational methods for solving systems of ODEs; experience with applied math techniques including averaging, bifurcation analysis, etc.; training in interdisciplinary research in mathematical neuroscience.
Mentoring Plan
Weekly meetings with the student to discuss progress and next steps as well as incorporation of the student into the active AMS Math Bio Research group.