Project Info
Synthesis and characterization of biopolymer-capped magnetic mesoporous silica nanomaterials (magnet-MSN) with stimuli-responsive release by enzymes produced in saliva
Brian Trewyn | btrewyn@mines.edu
This technology has utility in several different industries including personal health and cosmetics. It is interesting because if we can control the hydrolysis of biopolymers that encapsulate molecules we will realize a new method to deliver drug and bioactive molecules.
More Information
Prof. Trewyn group research website
Vivero-Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S.-Y. (2010). Mesoporous silica nanoparticles for intracellular controlled drug delivery. Small, 6(18), 1952–1967. http://doi.org/10.1002/smll.200901789
Deodhar, G. V.; Adams, M. L.; Trewyn, B. G. Controlled release and intracellular protein delivery from mesoporous silica nanoparticles. Biotechnol. J. 2017, 12 (1), 1600408.
Grand Engineering Challenge: Engineer better medicines
Student Preparation
Qualifications
Basic chemistry skills that are taught in the general chemistry courses.
Some organic synthesis skills.
Time Commitment
20 hours/month
Skills/Techniques Gained
Nanoparticle synthesis, nanomaterial characterization, potentially cell line maintenance.
Mentoring Plan
Regular individual meetings and team meetings with other undergrads and graduate students working on the project.