Project Info
*Nano-Flare Hydrogels: Urine-Color Changing Diagnostics for Transplant Rejection Detection
Dylan Domaille
ddomaille@mines.edu
Over 661,000 Americans live with end-stage renal disease (ESRD). Of these, about 193,000 live with a functioning kidney transplant. Current technology to monitor transplant health are either invasive (e.g., surveillance biopsy) or insensitive (e.g., serum creatinine measurements). We are developing hydrogel-based diagnostics that respond to chemical cues produced during transplant rejection to alert a patient that their transplant is undergoing stress.
More Information:
Grand Challenge: Engineer better medicines
http://domaillelab.com
Background on dynamic covalent chemistry: https://europepmc.org/article/ppr/ppr257865
Primary Contacts:
Mr. Gun Su Han (gunsuhan@mines.edu)
Dr. Dylan Domaille (ddomaille@mines.edu)
Student Preparation
Qualifications
Ideally, a strong background and interest in organic chemistry and a strong desire to learn synthetic organic chemistry in a research laboratory setting.
TIME COMMITMENT (HRS/WK)
5
SKILLS/TECHNIQUES GAINED
-Knowledge of synthetic organic chemistry and analytical chemistry (e.g., NMR)
-Knowledge of biomaterials synthesis
-Soft skills in presentations, notebook keeping, poster and manuscript preparation.
MENTORING PLAN
The student will have day-to-day interactions with a 4th-year graduate student, weekly sub-group meetings with Dr. Domaille & the graduate student, and biweekly group meetings with the full research group. Students will be expected to provide weekly updates during their subgroup meeting and present once a semester during group meeting to report their project progress.
PREFERRED STUDENT STATUS
Junior
Senior